Biomaterials for Stem Cell Engineering and Reprogramming
  • Seung-Woo Cho
  • SLS Colloquia / 2017.11.30.(Thu) 04:00pm / Room N104, Bldg 110
Abstract

Stem cells have shown huge potential as therapeutics for the treatment of incurable diseases, but their therapeutic efficacy sometimes needs to be further improved by promoting specific lineage differentiation required for tissue regeneration. Direct reprogramming can generate tissue-specific cell types for therapeutic applications, but low conversion efficiency still remains a major challenge. In my presentation, several biomaterial platforms will be introduced to promote neuronal differentiation of stem cells and direct conversion of fibroblast to neuronal lineage cells. Three-dimensional hydrogels with electroconductive nanomaterials and nanoscale patterned substrates for the reconstitution of neural stem cell microenvironments could promote neuronal differentiation and functional maturation of human neural stem cells. In addition, the platforms providing electrical stimulation and brain-mimicking extracellular matrix could facilitate polymer nanoparticle-mediated direct conversion of fibroblasts to functional induced neuronal cells for therapeutic purposes. The biomaterials reported here can present highly efficient biomedical platforms for improving stem cell therapy and reprogramming strategy for the treatment of neurodegenerative diseases.