DNA and polymeric nanoparticles for biomedical imaging and therapeutics
  • Minseok Kwak
  • SLS Colloquia / 05.25.2017. 04:00 pm / Room N104, Bldg 110.
Abstract

DNA has been extensively studied in the context of self-assembled nanostructures. Due to the specificity of DNA hybridization and programmability of the DNA codes, it is possible to create intricate and beautiful DNA structures on the nanoscale. This talk will mostly focus on a related class of materials, DNA amphiphiles that have synthetic hydrophobic segments covalently connected to oligonucleotides. These materials exhibit both the self-recognition properties of DNA and the aggregation behavior of amphiphilic macromolecules. DNA and polymeric micelles were used for in vivo ophthalmic delivery, immunology and imaging, which proved the potency of the materials for advanced therapeutics and bioimaging. Lastly, precisely defined DNA nanostructures, so called DNA origamis, will be briefly introduced as a novel system to introduce anisotropy to larger nanomaterials.