Bacterial Response to Chemical Stresses
  • Jung-Hye Roe
  • SLS Colloquia / 05.11.2017. 04:00 pm / Room N104, Bldg 110.

Bacteria inhabits in nearly all habitats that we can monitor in the biosphere of planet earth, biotic or abiotic environments with wide ranges of physical and chemical variations. They also exhibit diverse metabolic capabilities, encoded in their genome. More than two-thirds of natural products that are used as pharmaceuticals are derived from bacterial metabolites, the majority of which is from a single phylum Actinobacteria. We have studied bacterial response to chemical stresses in a model actinobacterium Streptomyces coelicolor, which undergoes morphological and physiological differentiation, producing a variety of secondary metabolites that includes antibiotics. Novel machineries and regulatory pathways have been unraveled to constitute the optimized response to sudden changes in the environment. How this brilliant bacterium responds to chemical stresses such as oxidants, metals, and antibiotics, encountered in natural habitats, will be presented. The principles and players of the responsive pathways will shed light on understanding, utilizing, and controlling not only closely related bacteria, and form the basis to abstract common principles behind stress responses in general.