- Eun Joo Roh
- SLS Colloquia / Oct 11th 04:00 pm / Engineering Building 1st E104
Several scaffolds with heterocyclic structures were prepared and evaluated as biological active compound. Novel quinazoline-urea analogues as modulators for Aβ-induced mitochondrial dysfunction and TMZ-resistant glioblastoma multiforme (GBM), 4-anilinoquinazoline hybrids as dual EGFR/HER2 inhibitors with cytotoxic activity against breast cancer and [1,2,3]triazolo[4,5-d]pyrimidine analogues as potential antiproliferative agents.
For the functional study of chloride channel ANO-1, focused compounds of anthranilic acid were prepared and MONNA was proved as best compound so far.