Multifunctional roles of ribosomal proteins in
  • Joon KIM
  • SLS Colloquia / Oct 06th 04:00 pm / Engineering Building 1st E104
Abstract

Our lab has discovered that eukaryotic ribosomal protein S3 (rpS3) is a multifunctional protein which plays a critical role through different post-translational modifications in humans and yeasts. Recently, we also have discovered that this protein is also involved in the repair of mitochondrial DNA damage through the translocation from the cytoplasm to the mitochondria upon excessive oxidative stress conditions. The function of rpS3 in the DNA repair processing is connected with cell viability, and the post-translational regulation mechanism determines the fate of rpS3 between a ribosomal component and a non-ribosomal soluble protein. Moreover, we will present novel data that rpS3 is involved in the cell homeostasis via protein quality control in humans and yeasts. We will also show data that this protein is involved in cancer metastasis via secretion of rpS3 protein after glycosylation. In conclusion, it works not only in protein synthesis but also in cancer related phenomena such as DNA repair, cancer and cell homeostasis.