[BIO Colloquium] Rebound synchronization commands Parkinsonian motor disorders
  • Daesoo Kim, Ph.D. (KAIST)
  • SLS Colloquia / Nov 11th 04:00 pm / AMRB 113
Abstract
 

Synaptic inhibition is the main mechanism that limits neuronal electrical signaling within the brain. Here we identify how inhibition induces abnormal motor signals during Parkinson’s disease (PD). Photostimulation of inhibitory presynaptic neurons in the ventrolateral thalamus induced synchronous rebound activity that yielded PD-like motor responses. De-synchronization of this rebound activity, by knock-out of the CaV3.1 gene, reduced PD-like motor responses, indicating that synchronization of rebound activity underlies PD-like motor responses. In a genetic model of PD, post-inhibitory rebound firing was highly synchronized and optogenetic blockade of inhibitory input greatly reduced the PD-like motor impairment seen in these mice. Our results indicate that thalamic inhibition mediates Parkinsonian motor disorders and acts by synchronizing rebound activity in thalamic neurons. These results shift thinking about PD toward an inhibition-based population coding mechanism.