[BME Colloquium] Therapeutic Applications of Photothermal Interactions
  • Hyun Wook Kang, Ph.D. (Pukyong National University)
  • SLS Colloquia / Nov 6th 04:00 pm / EB1 E104

Laser therapy has been studied and investigated for decades to improve clinical outcomes. Among various laser parameters, wavelength is one of the most significant parameters to efficiently and safely treat target diseases. In the current study, novel optical delivery devices were designed, developed, and evaluated to deliver laser light, to treat urological and gynecological disorders, and to identify the outcomes of minimally-invasive laser therapy in vitro and in vivo. Benign prostate hyperplasia and menorrhagia were selected as target diseases for 532-nm laser therapy. Ablation efficiency and coagulative necrosis were quantitatively estimated to demonstrate the performance of each newly designed optical device. For prostate thermal therapy, due to high light absorption by vascularized prostatic tissue, the laser light efficiently ablated the prostate with minimal thermal damage to the peripheral tissue, which helped facilitate tissue repair and resolve after healing. A histological evolution of tissue denaturation was well recognized after in vivo photothermal ablation in canine prostatic tissue. A thin coagulation layer of 2.0±0.4 mm was created, and partially damaged tissue was completed healed and re-epithelialized after 2 months. Regarding uterine thermal therapy, uniform distribution of laser light with good thermal insulation rapidly and specifically coagulated the endometrium layer in the uterine tissue without any injury to myometrium. In vivo photocoagulation in a caprine uterus horn demonstrated uniform tissue coagulation necrosis (2.8±1.2 mm) without any subjacent damage to a myometrium layer. Photothermal therapy by means of the newly designed optical devices can be minimally-invasive ways to efficiently and safely treat urological and gynecological disorders.