[BME Colloquium]Biophotonic in vivo reading and writing technologies with animal models of brain disease
  • Euiheon chung,Ph.D. (GIST)
  • SLS Colloquia / April 3rd 04:00pm / EB1 E104

Biophotonics has provided indispensable tools in biomedical research. In vivo imaging or ‘reading' of small animals bearing tumor offers a unique opportunity to understand tumor progression and treatment monitoring in cancer research. In addition I introduce the use of light for ‘writing' including neuromodulation or deep tissue light delivery. The use of novel optical technologies to study brain metastasis from breast cancer will be illustrated. In vivo imaging can reveal complex cellular behaviors of cancer at various length scales. At the whole-body/tissue scale, I introduce whole-body bioluminescence imaging. A novel secreted Gaussia luciferase based assay can localize and quantify systemic tumor metastases to monitor tumor progression and response to treatments. At the cellular scale, I introduce video-rate two-photon microscopy to visualize the dynamic nature of tumor vasculature in a mouse brain with cellular resolution. On-going research on functional brain imaging as well as optical and optogenetic neuromodulation will also be discussed. These multiple scale reading and writing technologies with clinically meaningful animal models provide us fundamental insight into preclinical research and help developing translational therapeutic strategies.